import requestsimport urllib3urllib3.disable_warnings()def fetch_uniprot_data(uniprot_id): url =f"https://rest.uniprot.org/uniprotkb/{uniprot_id}.json" response = requests.get(url, verify=False) # Disable SSL verification response.raise_for_status() # Raise an error for bad status codesreturn response.json()def display_uniprot_data(data): primary_accession = data.get('primaryAccession', 'N/A') protein_name = data.get('proteinDescription', {}).get('recommendedName', {}).get('fullName', {}).get('value', 'N/A') gene_name = data.get('gene', [{'geneName': {'value': 'N/A'}}])[0]['geneName']['value'] organism = data.get('organism', {}).get('scientificName', 'N/A') function_comment =next((comment for comment in data.get('comments', []) if comment['commentType'] =="FUNCTION"), None) function = function_comment['texts'][0]['value'] if function_comment else'N/A'# Printing the dataprint(f"UniProt ID: {primary_accession}")print(f"Protein Name: {protein_name}")print(f"Organism: {organism}")print(f"Function: {function}")# Replace this with the UniProt ID you want to fetchuniprot_id ="Q3KNW5"data = fetch_uniprot_data(uniprot_id)display_uniprot_data(data)
UniProt ID: Q3KNW5
Protein Name: Sodium-dependent organic anion transporter
Organism: Homo sapiens
Function: Transports sulfoconjugated steroid hormones from the extracellular compartment into the cytosol in a sodium-dependent manner without hydrolysis (PubMed:17491011, PubMed:23667501, PubMed:24717977, PubMed:28951227). Steroid sulfate hormones are commonly considered to be biologically inactive metabolites, that may be activated by steroid sulfatases into free steroids (PubMed:23667501, PubMed:24717977). May play an important role by delivering sulfoconjugated steroids to specific target cells in reproductive organs (By similarity). May play a role transporting the estriol precursor 16alpha-hydroxydehydroepiandrosterone 3-sulfate (16a-OH-DHEAS) at the fetal blood vessel endothelium (PubMed:24717977). Can also transport other sulfoconjugated molecules such as taurolithocholic acid-3-sulfate and sulfoconjugated pyrenes (PubMed:17491011)
More information:
AlphaFold model
Surface representation - binding sites
The computed point cloud for pLDDT > 0.6. Each atom is sampled on average by 10 points.
To see the predicted binding interfaces, you can choose color theme “uncertainty”.
Go to the “Controls Panel”
Below “Components”, to the right, click on “…”
“Set Coloring” by “Atom Property”, and “Uncertainty/Disorder”